General Information

  • ID:  hor001450
  • Uniprot ID:  P31889
  • Protein name:  Neuropeptide AF1
  • Gene name:  NA
  • Organism:  Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
  • Family:  FARP (FMRFamide related peptide) family
  • Source:  Animal
  • Expression:  Found in the nerve cords and a variety of ganglia particularly in the anterior regions.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  KNEFIRF
  • Length:  7(1-7)
  • Propeptide:  KNEFIRF
  • Signal peptide:  NA
  • Modification:  T7 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Potent modulator of inhibitory motorneurons. Reduces the input resistance and blocks slow oscillatory potentials in these cells.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001450_AF2.pdbhor001450_ESM.pdb

Physical Information

Mass: 106030 Formula: C45H68N12O11
Absent amino acids: ACDGHLMPQSTVWY Common amino acids: F
pI: 9.69 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: -75.71 Boman Index: -2304
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 55.71
Instability Index: 857.14 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2627377
  • Title:  AF1, a Sequenced Bioactive Neuropeptide Isolated From the Nematode Ascaris Suum